Flotillin function

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August undefined, 2024

WebAnother flotillin role is to facilitate efficient protein complex assembly, which is probably why flotillin perturbation affects the function of FMM-associated signal transduction … WebMay 24, 2016 · Flotillin-1 (Flot1, reggie-2) is a lipid raft-associated scaffolding protein that belongs to a family of proteins characterized by an evolutionarily conserved SPFH domain (Browman et al., 2007; Langhorst et al., 2008).Although flotillin-1 is ubiquitously expressed, it is known to be highly expressed in brain tissue, and has been shown to serve distinct …

Flotillin 1 - an overview ScienceDirect Topics

WebMar 26, 2024 · Additional functions unique to flotillin-1 have been discovered recently. The membrane-binding of flotillins is regulated by S-palmitoylation and N-myristoylation, … WebJan 1, 2012 · Flotillins are membrane proteins that form microdomains in the plasma membrane of all mammalian cell types studied to date. They span the evolutionary spectrum, with proteins related to flotillins... harlow new town

Essential role of flotillin-1 palmitoylation in the intracellular ...

WebJan 21, 2014 · The function of flotillin microdomains is not fully understood, but they are likely to be important for linking the plasma membrane and the cytoskeleton [10] – [12], for signaling events [13], … Weborganelles. Interestingly, flotillin is a close homologue of ESA1 (epidermal surface antigen (33)), and together they define a new “flotillin family” of caveolae-associated integral … WebFlotillin-2/ESA (e pidermal s urface a ntigen) plays a role in intercellular epidermal adhesion.Epidermal surface proteins have an important role in normal epidermal maintenance and function. In addition, they are involved in various autoimmune diseases in which auto-antibodies bind to normal epidermal cell surface proteins. harlown tyrner

Molecular characterization and function of the lipid raft protein ...

WebJan 21, 2014 · The function of flotillin microdomains is not fully understood, but they are likely to be important for linking the plasma membrane and the cytoskeleton –, for signaling events , , for regulating … WebJun 1, 2015 · More importantly our data show the regulatory function of flotillin-1 palmitoylation turnover in the plasma membrane – a dynamic IGF-1-induced process of … chantals pyjama party 2022WebFlotillin-1 and -2 ... At a Keystone Symposium on Lipid Rafts and Cell Function in 2006, a consensus was reached that the term ‘lipid rafts’ should be changed to ‘membrane rafts’ recognizing the role of raft proteins, and that caveolae should be considered a membrane raft. Another issue which was discussed at that meeting and that has ... chantals pyjama party gemist

"WebJan 1, 2015 · To investigate the potential functions of FLOT2 in cervical cancer progression, we measured the expression pattern of FLOT2 in 115 archived cervical … " - Flotillin function

Flotillin function

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WebJun 1, 2015 · Here, we explored flotillin-1-mediated regulation of insulin-like growth factor-1 (IGF-1) signaling. Flotillin-1-deficient cells exhibited a reduction in the activation of IGF-1 receptor (IGF-1R), ERK1/2 and Akt pathways, and the transcriptional activation of Elk-1 and the proliferation in response to IGF-1 were reduced in these cells. WebJun 1, 2015 · Flotillin-1 (also known as reggie-2) and flotillin-2 (also known as reggie-1) are membrane-associated oligomeric proteins that are ubiquitously expressed ( Lang et al., 1998; Neumann-Giesen et al., 2004; Solis et al., 2007; Stuermer et al., 2001 ).

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WebFeb 19, 2014 · For a review on flotillin functions in general, the reader is referred to two recent review articles [1,2]. The MAP kinase signaling cascade is the canonical …

WebApr 1, 2009 · Flotillin-1 and flotillin-2 co-assemble into plasma membrane microdomains that are involved in the endocytosis of molecules such as glycosyl phosphatidylinositol (GPI)-linked proteins. Previous studies suggest that budding of flotillin microdomains from the plasma membrane is a tightly regulated process. WebDec 1, 2011 · They span the evolutionary spectrum, with proteins related to flotillins present in bacteria, fungi, plants and metazoans, which suggests that they perform important, …

WebThe formation of the face in vertebrate animals is a complex and precisely orchestrated process involving the sequential migration, proliferation and … WebAug 1, 2024 · Flotillin-1 and -2 are markers of membrane rafts but their true endothelial function is unknown. We hypothesized that flotillins are required for TLR signaling in …

WebNov 27, 2009 · These results imply that flotillins are conserved between plants and animals. The conserved subcellular localization suggests the possibility of conserved function(s). …

WebThe function of flotillin 1 has not been determined. Synonyms. DADB-118P11.2; Flot1; flotillin 1; Flotillin-1; I79_013152; integral membrane component of caveolae; … chantal square baking dishWebNov 27, 2009 · These results imply that flotillins are conserved between plants and animals. The conserved subcellular localization suggests the possibility of conserved function(s). In this work, we employ a reverse genetics approach to investigate the role of the Medicago truncatula flotillin-like gene family (FLOTs) in symbiosis. chantal stainless steel classic tea kettleWebImmunogen: Mouse Flotillin aa. 312-428 Application: Western blot (Routinely Tested), Immunofluorescence (Tested During Development) Target Molecular Weight: 48 kDa Concentration: 250 µg/ml RRID: AB_398139 Storage Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. Regulatory Status: RUO View All … harlow occupational health service ltdWebFlotillin-1 and -2 ... At a Keystone Symposium on Lipid Rafts and Cell Function in 2006, a consensus was reached that the term ‘lipid rafts’ should be changed to ‘membrane rafts’ … harlow news pondWebMay 28, 2024 · Functions of flotillins include cell signal transduction, cell-cell contact regulation, membrane-cytoskeletal interaction, and clathrin-independent endocytosis ( 16 – 18 ). chantal stainless steel classic teakettleWebJul 3, 2024 · Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are associated with obesity. They are accompanied by increased levels of free cholesterol in the liver. Most free cholesterol resides within the plasma membrane. We assessed the impact of adding or removing free cholesterol on the function and … chantals pyjama party liveWebNational Center for Biotechnology Information chantal stainless steel