Cytosolic binding
WebApr 11, 2024 · In this study, Zhu and colleagues discovered that the orphan nuclear receptor Nur77 is required for NLRP3 inflammasome activation downstream of caspase-11-mediated GSDMD cleavage. Nur77 binds to both cytosolic mtDNA and LPS via its DNA-binding domain (DBD) and ligand-binding domains (LBDs), respectively. This allows Nur77 to … WebOct 2, 2014 · The insulin-induced increase in cytosolic glucose in these cells is due to an imbalance between the glucose transported into the cytosol and the use of glucose in the cytosol. ... We used a FRET-based glucose nanosensor, FLIPglu-600µ. On binding of glucose to the nanosensor, a decrease in the fluorescence ratio between fluorophores …
Cytosolic binding
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WebLigand binding, however, changes the picture: the GPCR is activated and causes the G protein to exchange GDP for GTP. The now-active G protein separates into two pieces (one called the α subunit, the other consisting … WebApr 1, 2024 · cGAS and AIM2 are CDSs that are activated in the presence of cytosolic dsDNA and are expressed in various cell types, including immune and tumor cells. The recognition of tumor-derived dsDNA by CDSs in the cytosol of tumor-infiltrating dendritic cells (TIDCs) activates the innate and acquired immunity, thereby enhancing anti-tumor …
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WebApr 11, 2024 · Nur77 binds to both cytosolic mtDNA and LPS via its DNA-binding domain (DBD) and ligand-binding domains (LBDs), respectively. This allows Nur77 to interact with the leucine-rich repeat region of NLRP3, inducing the recruitment of NEK7 and promoting inflammasome activation and casapse-1-dependent cleavage of IL-1β. WebMay 30, 2013 · Cytosolic DNA arising from intracellular bacterial or viral infections is a powerful pathogen-associated molecular pattern (PAMP) …
WebAug 31, 2024 · ALG-2 is a penta-EF-hand Ca2+-binding protein and interacts with a variety of proteins in mammalian cells. In order to find new ALG-2-binding partners, we searched a human protein database and retrieved sequences containing the previously identified ALG-2-binding motif type 2 (ABM-2). After selecting 12 high-scored sequences, we …
WebNational Center for Biotechnology Information pinewood derby award categoriesWebCytolysin refers to the substance secreted by microorganisms, plants or animals that is specifically toxic to individual cells, in many cases causing their dissolution through … pinewood derby awards categoriesWebAs soluble cytosolic zinc-binding proteins are thought to be key mediators of steady state cytosolic zinc ion buffering and muffling reactions, knowledge of their macroscopic and microscopic binding constants for zinc ions is critical for … pinewood derby award certificatesWebApr 6, 2024 · We demonstrate that the crucial activity of Tom70 is its ability to recruit cytosolic chaperones to the outer membrane. Indeed, tethering an unrelated chaperone … pinewood derby axle drill bitWebJun 11, 2024 · In ER targeting, Hsp70 [82,83,84] or calmodulin have been reported to function as cytosolic binding factors, and Sec72 has been suggested to play the role of a membrane receptor for Hsp70 in yeast . In mitochondrial import, the presequences are recognized by membrane receptors Tom20/Tom22 or Tom70, with the assistance of … pinewood derby awards ideasWebAntigen processing, or the cytosolic pathway, is an immunological process that prepares antigens for presentation to special cells of the immune system called T lymphocytes. It is considered to be a stage of antigen presentation pathways. pinewood derby awardsWebApr 6, 2024 · We demonstrate that the crucial activity of Tom70 is its ability to recruit cytosolic chaperones to the outer membrane. Indeed, tethering an unrelated chaperone-binding domain onto the mitochondrial surface complements most of the defects caused by Tom70 deletion. Tom70-mediated chaperone recruitment reduces the proteotoxicity of … pinewood derby award ideas